Rebuilding the World, From the Bottom Up
Excelsior Sciences leverages chemistry that machines can do. Blocc chemistry transforms small-molecule innovation into a simple, modular, iterative process—friendly to automation, AI, and non-specialists—with seamless scaling from discovery to manufacturing. We’re starting with medicines. We’re reimagining everything.
Shattering Chemistry’s 200-Year-old Bottleneck
Small molecules, the class of chemical matter primarily built from C-C bonds, power everything from medicines to materials, but making them fast enough for modern AI is not possible due to the manual nature of small molecule synthesis. We’re changing that with smart bloccs—machine-ready chemical building blocks that let automation, not artisanship, drive synthesis and accelerate discovery.
Blocc Chemistry
A New Language for Chemistry
Blocc Chemistry
Iterative carbon-carbon bond formation that is friendly to automation, AI, and non-specialists. It is foundational for a new chemistry language model in which smart bloccs = tokens.
Closed-loop Learning
AI-guided automated iterative synthesis and testing to maximize accuracy of foundation models for predicting multiple general molecular properties, such as solubility, permeability, toxicity, and metabolism for pharmaceuticals. The goal is to minimize model uncertainty.
Closed-loop Discovery
AI-guided leveraging of foundation models and automated iterative synthesis and testing to discover small molecules with multiple targeted functional properties. The goal is to optimize objective functions.
Key Benefits
Speed With Certainty
Rapid, iterative closed loop learning cycles powered by uncertainty-minimizing AI models
Broader Exploration
Broader exploration: Machines link the digital and physical worlds, so scientists can pursue more ideas
Strategic Resilience
Local, automated production strengthens supply chains and enables reshoring
Scale on Demand
The same platform that makes the first milligrams readily scales to kilograms
Resources
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BlogExcelsior Sciences completes Series A and unveils partners to change how small molecules are discovered and manufactured
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News and Press ReleasesExcelsior Sciences Raises $95 Million to Transform Small Molecule Discovery and Manufacturing with Novel Chemistry that Machines Can Do
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Scientific PublicationsClosed-loop transfer enables artificial intelligence to yield chemical knowledge
Our Team
Excelsior is led by pioneers at the intersection of chemistry and AI: CEO Michael Foley, Ph.D. and COO Jana Jensen, PhD, MBA, alongside renowned scientists Marty Burke, M.D., Ph.D. and Bartosz Grzybowski, Ph.D. Backed by investors including Deerfield, Khosla Ventures and Sofinnova Partners, our team bridges cutting-edge science with real-world impact.
